• Integrative Doctor

NAD+ could help treat COVID-19 patients, scientists say.

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme that is central to cellular metabolism.



NAD+ acts as a catalyst in the processing of nutrients and is essential in converting nutrients to energy, as well as modulating immune response to viral infections.


Scientists in Bahrain have published a paper stating that COVID-19 infection can result in reduced NAD+ levels in our cells, and that restoring NAD+ levels could be an important treatment for patients with the illness.


NAD+ levels are known to diminish with age, which can reduce the effectiveness of the body’s immune response. Death rates from COVID-19 increase with age.


One possible reason for the depletion of NAD+ in COVID-19 patients is related to a large protein called poly-ADP ribose polymerase-1 (PARP-1). PARP-1 helps catalyse the breakdown of NAD+ to perform its antiviral work, but the SARS-CoV-2 virus that causes COIVD-19 inhibits its effectiveness, leading to excessive PARP-1 activation and an inflammatory response.


This leads to increased consumption of NAD+, inhibiting cellular energy and resulting in cell death.


Writing in the Journal of Infection and Public Health, the Bahrain researchers suggest that restoring normal NAD+ levels in older COVID-19 patients could decrease the severity of their immune response and improve their overall health condition.


At PIM we have a particular interest in the role of micronutrients in our health and wellbeing. Contact us to learn more.


Click here to read more detail about the research.


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