• Integrative Doctor

COVID-19 mortality and NAD+ deficiency – what is the link?

A new hypothesis from South African medical researchers suggests that a deficiency of nicotinamide adenine dinucleotide (NAD+) may be the primary factor in the risk of death from COVID-19.



Older patients and those with several conditions linked to oxidative stress are more likely to die from COVID-19.


NAD+ levels are reduced in older people, and also in those who suffer from conditions noted for oxidative stress such as type 2 diabetes, obesity and hypertension. NAD+ is vital for cellular metabolism, so further depletion of NAD+ levels as a result of COVID-19 could lead to the disease progressing to the hyperinflammatory stage that can cause death.


The new research looks at the role of a protein known as SIRT1, which controls and modifies the inflammatory response and plays a role in defending against viral infections. A lack of NAD+ limits the production of SIRT1 and therefore reduces the body’s immune response against the virus.


The researchers conclude that nutritional support with NAD+ precursors and SIRT1 – both in advance of infection and as a treatment for infected patients – could minimise the severity of COVID-19.


There is more research to be done, but if the hypothesis is proven it could have broad ramifications for the treatment of COVID-19, especially in the third world.


At PIM we have a particular interest in the role of micronutrients in our health and wellbeing.


Contact us to learn more.


Click here to read more detail about the research.


50 views0 comments

Recent Posts

See All