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NAD+ (Nicotinamide Adenine Dinucleotide) Patient Information

What is NAD+?

  • Nicotinamide Adenine Dinucleotide (NAD+) is a cell co-enzyme recognised for its regenerative effects on mitochondria (the engines that drive energy in our cells and bodies)

  • Its purpose is to fuel metabolic reactions, by increasing ATP (cellular energy), similar to petrol in your car

  • Without NAD+, your cells can’t metabolise carbohydrates, fats and amino acids

  • Supplementation with NAD+ may support the removal of dysfunctional mitochondria whose presence has been implicated in a wide range of conditions, including fatigue syndromes, and in aging

  • The use of NAD+ in medicine is currently considered experimental.

NAD+ and Wellbeing

​NAD+ may be supportive in:

  • Parkinson’s disease

  • Dementia/Alzheimer’s disease

  • Drug and alcohol withdrawal or addiction disorders

  • Traumatic brain injury and concussion

  • Stress and fatigue syndromes

  • Sports and training

Dosing and Administration
  • PIM provides infusions of 500mg NAD+, delivered intravenously in saline through a ‘drip’.

  • A ‘loading’ dose protocol of 4 infusions over 2-3 weeks is recommended, followed by a maintenance dose every 6-8 weeks.

  • NAD+ cannot be mixed with other IV nutrients, however the NAD +procedure may be used in conjunction with other injectable nutrients (Vitamin C, B complex) following NAD+ on the same or alternative days.

Risks and Side Effects
  • The NAD+ infusion procedure is very safe, however some patients experience sensations of warmth or aching during the procedure.

  • These are only temporary and resolve when the infusion is slowed down.

  • Patients are encouraged to use distractions (reading, listening to music, watching a video on a device) if required.

  • No long term adverse events or hospitalisations have been reported in relation to NAD+.

  • This means that for some patients, the infusion needs to be given over a longer period of time - up to 3 hours.

  • We therefore advise patients to allocate at least 3 hours for the infusion.

Terms and Conditions
  • NAD+ infusions are manufactured by a compounding pharmacy on an individual ‘per patient’ basis and unlike other injectable nutrients, have a very short storage life after manufacturing – only 7 days.

  • Consequently, an up-front deposit will be required in order to secure a booking of NAD+ infusions at PIM. The remaining balance for the procedure is payable on the day of attendance.

  • Should it be necessary to cancel your NAD+ procedure, we are unable to refund the deposit, as it will not possible to use this for another patient.

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